MicroLyte® Ag Antimicrobial Matrix

A One-of-a-Kind Combination

The all-new MicroLyte® Ag Antimicrobial Matrix brings a unique combination of characteristics in a wound care product.


MicroLyte® Ag Matrix is an ultrathin, fully-synthetic bioresorbable matrix composed primarily of a bioresorbable polyvinyl alcohol sheet with a polymeric surface coating containing ionic and metallic silver.  The matrix maintains a physiologically moist microenvironment.  This environment is conducive to granulation tissue formation, cell growth, and neovascularization.  Because the matrix material is bioresorbable, the matrix never needs to be removed from the wound.


MicroLyte® Ag Matrix contains antimicrobial silver in the matrix which kills bacteria in contact with the matrix and combats bacteria in deep wound tissue. Reduction of bacterial bioburden may reduce microbial colonization and risks of wound infection.  The addition of both ionic and metallic silver provides rapid, effective, and sustained antimicrobial activity.

  • 510k-cleared for 3-day antimicrobial effect
  • >99.99% effective against a broad spectrum of wound-related microbes

The conformability of MicroLyte® Ag Matrix means that it remains highly effective even with low amounts of silver, translating to:

  • Less wound staining
  • Lower residual tissue toxicity

Fully Synthetic.

Because MicroLyte® Ag Matrix is 100% synthetic there is no chance of disease transmission from animal-derived products.

The combination of these characteristics allows MicroLyte® Ag Matrix to be your first choice in wound care.

Product Application

MicroLyte® Ag Matrix is easy to apply. Once removed from its pouch and placed on a moist wound bed, MicroLyte® Ag Matrix immediately begins to hydrate and conform to the fine contours of the wound bed. Within seconds, the dressing has completely adhered to the wound and can be covered with the secondary dressing preferred for a given wound.

To reapply, carefully remove the secondary cover dressing. Gently irrigate wound with sterile saline to remove necrotic tissue. It is not necessary to remove any residual MicroLyte® Ag Matrix observed during secondary cover dressing changes.

Indications for Use

MicroLyte® Ag Matrix is indicated for the management of wounds and can be used over-the-counter for minor wounds such as abrasions and lacerations, minor cuts, and minor scalds and burns. Under the direction of a healthcare professional, MicroLyte® Ag Matrix may be used for more serious wounds such as partial and full thickness pressure ulcers, venous stasis ulcers, diabetic ulcers, first and second degree burns, abrasions and lacerations, donor sites and surgical wounds. MicroLyte® Ag Matrix may be used over debrided and grafted partial thickness wounds.

Chronic Wounds

Diabetic Foot Ulcers, Venous Leg Ulcers, Pressure Ulcers


First and Second Degree Burns

Surgical Wounds

Surgical Incisions, Moh’s Surgery, Reconstruction Surgery

Skin Grafts

Donor Sites, Debrided and Grafted Partial Thickness Wounds


“Less silver is more effective for wound management. MicroLyte® Ag Matrix has realized that paradigm shift in practice.”

– Dr. Michael J. Schurr, MD (Inventor)

Clinical Cases

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Mechanism of Action

MicroLyte® Ag Antimicrobial Matrix absorbs wound fluid and forms a soft material that conforms to the wound surface and maintains a moist environment. The dressing contains silver only to prevent or minimize microbial growth within the dressing. MicroLyte® Ag Matrix is so thin that it inherently conforms to the underlying contours of a moist wound-bed, providing intimate contact with the microbes on wound-bed. Antimicrobial silver in MicroLyte® Ag Matrix kills bacteria that come into contact with the dressing, and reduces microbial colonization. This action reduces loss of silver in wound exudate and provides effective antimicrobial action at much lower silver concentrations. Reduction of bacterial bioburden may reduce microbial colonization and risks of wound infection.

Product Specifications

MicroLyte® Ag Matrix is individually packaged in a sterile foil pouch a supplied sterile in boxes of 5 units. Sterilization by E-beam radiation. Sterility is guaranteed unless pouch is damaged or opened. Single use only.

REF. 91001- 2 inch x 2 inch (5 cm x 5 cm), (HCPCS Code A6242)
REF. 91002- 4 inch x 4 inch (10 cm x 10 cm), (HCPCS Code A6243)

MicroLyte® Ag Matrix Brochure

MicroLyte® Ag Matrix User Guide

Instructions for Use

HCPCS Code Verification Letter

Request Samples

Safety and Efficacy

Antimicrobial Efficacy

Unlike traditional antimicrobial dressings, Imbed’s ultrathin Microfilm™ technology enables MicroLyte® Ag Matrix to conform intimately to the tissue of a wound bed. By exerting sustained antimicrobial activity of silver (Ag) for up to 72 h in the microscopic environment of the wound tissue, it kills > 99.99% CFU (colony forming units) of clinically relevant microbes at 100x lower level of antimicrobial silver compared to other dressings.


The biocompatibility profile of the MicroLyte® Ag Matrix was assessed in accordance with ISO-10993: Biological Evaluations of Medical Devices. The biocompatibility test results demonstrate that MicroLyte® Ag Matrix is biocompatible and safe for for use in management of partial and full thickness wounds including pressure ulcers, venous ulcers, diabetic ulcers, first and second degree burns, abrasions and lacerations, donor sites and surgical wounds, and debrided and grafted partial thickness wounds.

MicroLyte® Ag Matrix vs. Traditional Wound Dressings and Matrices

Antimicrobial dressings and matrices are vital to managing bioburden in stalled wounds, thus allowing normal healing to proceed. Increasingly, higher levels of silver are being used to achieve greater antimicrobial activity. These excessive levels of silver, however, result in severe staining of the wound and inhibit re-epithelialization due to tissue toxicity.

The technology behind the MicroLyte® Ag Matrix results in an effective, yet gentle antimicrobial dressing. Unlike traditional silver dressings which are crude, high-capacity reservoirs of silver, MicroLyte® Ag Matrix conforms to contours of underlying wound bed resulting in antimicrobial action in the local microscopic environment of the wound bed where microbes colonize, allowing silver to be effective at very low concentrations. Based on Imbed’s patented ultrathin Microfilm™ technology platform, the MicroLyte® Ag Matrix is just 20 microns thick and it contains 10-500x less silver compared to the leading silver-based antimicrobial dressings. Yet the antimicrobial silver in MicroLyte® Ag Matrix kills >99.99% of a broad spectrum of bacteria and yeast in contact with the matrix, including MRSA and VRE stains. Ionic and metallic silver in the matrix provides sustained antimicrobial activity for up to 3 days.

This reduces silver loss in wound exudate, and the associated toxicity, irritation, and costs, while increasing comfort for patients. MicroLyte® Ag Matrix ultimately bioresorbs, thus eliminating the need for painful dressing removal.

No other product combines bioresorbability and antimicrobial activity in a fully synthetic matrix.

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I was surprised at the improvement in chronic wounds that did not appear
to have bacterial burden but were stalled in healing.
It worked well in diabetic foot ulcers, especially under the
total contact cast.
General & Critical Care Surgeon, Mission Hospitals, Asheville, NC


It is very simple to use- doesn’t require any preparation.
Unlike other dressings that sit on top, Microlyte Ag visually conforms
to wound surface and gives clear observation that it is getting to work.
Visually more intimate contact with the wound than other dressings.
Vascular Surgeon, University of North Carolina School of Medicine, Chapel Hill, NC


Patients and providers love that they can see the dressing getting
to work at the application. Patients liked gentle application and lack
of pain during dressing change. Providers like ease of use and application.
Nurse Practitioner, Ascension-Ministry Saint Michael’s Hospital, Stevens Point, WI


Low silver content allows antimicrobial plus regenerative therapy
at the same time. I can do it all at the same time.
Vascular Surgeon, Mount Sinai Hospital, New York, NY


The ultrathin transparent film architecture is novel and unique.
We like that the dressing can be rinsed off the wound, but doesn’t have to be
‘dug out’ like other dressings. No silver presence or staining
after application is attractive.
Dermatologist & Cutaneous Surgeon, MD, University of Miami Hospital, Miami, FL


We have trialed Microlyte Ag on three patients with amazing results. My team loves it.
Plastic & Reconstructive Surgeon, University of Nebraska Medical Center


I will continue to consider MicroLyte Ag Matrix as one of the tools in my wound healing box.
Amelia Beatty, Nurse Practitioner, Duke Wound Center


We like using this a lot, especially in wounds that have an irregular surface. It conforms to the wound base very readily. [The multi-day antimicrobial effect] is nice for wounds that may require compression or a secondary dressing that we don’t want to change everyday.”
Dr. Jeffrey A. Niezgoda, Medical Director, AZH Wound and Vascular